Description

Description & Mechanism

IGF-1 LR3 is a synthetic analogue of human insulin-like growth factor-1 (IGF-1) incorporating an arginine substitution at position 3 and an extended N-terminal sequence. These structural modifications reduce affinity for endogenous IGF binding proteins, resulting in altered stability and interaction characteristics in experimental systems compared to native IGF-1.

In biochemical and cellular research models, IGF-1 LR3 interacts with the IGF-1 receptor (IGF-1R), initiating intracellular signalling cascades associated with growth factor–mediated pathways. Research studies commonly examine receptor binding behaviour, downstream signalling kinetics, and comparative responses relative to native IGF-1. Observed molecular effects are dependent on experimental design, concentration, and model system and are used to investigate IGF-1 receptor signalling rather than defined biological or physiological outcomes.

Applications in Research

As a molecular tool for studying IGF-1 receptor binding and activation dynamics
Investigation of growth factor–mediated intracellular signalling pathways
In vitro studies comparing modified and native IGF-1 analogues
Use as a reference compound in endocrine and peptide signalling research

Handling, Reconstitution & Stability

Weigh under dry conditions; peptide is hygroscopic
Reconstitute in sterile water or appropriate buffered aqueous solution depending on assay requirements
Avoid vigorous agitation during dissolution
Filter sterilize if required (e.g. 0.22 µm) immediately prior to use
Aliquot and store reconstituted solutions at –20 °C (or lower) to minimise degradation
Avoid repeated freeze–thaw cycles

Specifications Summary

Parameter	Typical Value / Range
Purity (HPLC)	≥ 99 %
Appearance	White to off-white lyophilised powder
Molecular Weight	~9117.5 g/mol
Peptide Type	Synthetic IGF-1 analogue
Solubility	Water, buffered aqueous solutions
Storage	–20 °C, desiccated, dark
Pack Size	1 mg

Precautions & Notes

Experimental behaviour of IGF-1 LR3 is influenced by receptor expression, concentration, and exposure duration
Modified IGF-1 analogues may exhibit signalling profiles distinct from native IGF-1
Buffer composition, pH, and ionic strength may affect peptide stability and assay performance
Appropriate controls are recommended to distinguish specific from non-specific effects
Intended strictly for laboratory research use; not for human or veterinary application

My Account

Checkout

Customer Support

IGF1-LR3 1mg

Guaranteed Safe Checkout