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Pancragen 20mg
Pancragen 20mg
Pancragen 20mg
Pancragen 20mg
Pancragen 20mg
Pancragen 20mg
Pancragen 20mg

Pancragen 20mg

£40.90

  • OP Labs formerly Oxford Peptides
  • Batch tested Purity: ≥ 98.5 % (HPLC, typical)
  • CAS Number: 42464-96-0
  • Molecular Formula: C₁₀H₁₁N₂⁺
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ALL ARTICLES AND PRODUCT INFORMATION PROVIDED ON THIS WEBSITE ARE FOR INFORMATIONAL AND EDUCATIONAL PURPOSES ONLY.

The products offered on this website are furnished for in-vitro studies only. In-vitro studies are performed outside of the body. These products are not medicines or drugs and have not been approved to prevent, treat or cure any medical condition, ailment or disease. Bodily introduction of any kind into humans or animals is strictly forbidden.

Description

Description & Mechanism

Pancragen (KEDW / KEDW-NH2) is studied in vitro as a pancreas-directed short-peptide probe. In aged human pancreatic cell cultures it has been reported to increase expression of proliferation markers (Ki-67, PCNA) and matrix metalloproteinases, and to alter apoptosis-associated proteins, used experimentally to study acinar/islet differentiation and cell-renewal signalling.

It functions as a molecular tool for probing transcriptional control of pancreatic endocrine/exocrine differentiation and glucose–insulin axis biomarkers in cellular and preclinical models. Observed effects depend on concentration, model system and exposure conditions; no physiological outcome is implied.

Applications in Research

  • In-vitro study of pancreatic acinar / islet cell differentiation and proliferation/apoptosis markers
  • Preclinical (rodent / aged-primate) models of pancreatic functional decline
  • Investigation of peptide effects on glucose–insulin axis biomarkers in experimental systems
  • Probe for tissue-specific transcriptional regulation

Specifications Summary

Parameter Typical Value / Range
Purity (HPLC) ≥ 99 %
Appearance White to off-white lyophilised powder
Molecular Weight 576.25 g/mol
Peptide Type Synthetic tetrapeptide bioregulator (Khavinson cytogen family; pancreas)
Solubility Water, buffered aqueous solutions
Storage –20 °C, desiccated, dark
Pack Size 20 mg (total)

Handling, Reconstitution & Stability

  • Weigh under dry conditions; peptide is hygroscopic
  • Reconstitute in sterile water or appropriate buffered aqueous solution depending on assay requirements
  • Avoid vigorous agitation during dissolution
  • Filter sterilize if required (e.g. 0.22 µm) prior to use
  • Aliquot and store reconstituted solutions at –20 °C or below to minimise degradation
  • Avoid repeated freeze–thaw cycles

Precautions & Notes

  • Confirm whether the supplied material is the free-acid (KEDW) or amidated (KEDW-NH2) form against the batch CoA; molecular weights differ
  • Experimental behaviour is dependent on concentration, model system and exposure conditions
  • Prolonged exposure to light, elevated temperature or aqueous environments may reduce stability
  • Intended strictly for laboratory research use; not for human or veterinary application

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