PE-22-28 5mg

Description

Description & Mechanism

PE-22-28 is a synthetic peptide corresponding to amino acids 22–28 of pancreatic polypeptide (PP), an endogenous peptide hormone involved in neuroendocrine signalling. The fragment represents a structurally defined region commonly used in research to study sequence-specific peptide–receptor interactions independent of the full-length parent molecule.

In biochemical and cellular research systems, PE-22-28 has been investigated for its interaction with Y-family peptide receptors and its role in modulating peptide signalling pathways associated with pancreatic and neuroendocrine communication. Experimental observations are dependent on model system, receptor expression, concentration, and exposure duration, and are used to explore signalling mechanisms rather than defined physiological outcomes.

Applications in Research

• As a molecular probe for studying pancreatic polypeptide–derived signalling
• Investigation of Y-receptor binding and peptide–receptor interaction dynamics
• In vitro studies examining structure–function relationships of PP fragments
• Use as a reference compound in neuroendocrine and peptide signalling research

Specifications Summary

Purity: ≥ 99 %
Appearance: White to off-white lyophilised powder
Peptide Type: Synthetic pancreatic polypeptide fragment
Molecular Weight: ~773.89 g/mol
Solubility: Water, buffered aqueous solutions
Storage: –20 °C, desiccated, protected from light
Pack Size: 5 mg

Precautions & Notes

• Experimental behaviour of PE-22-28 is influenced by receptor expression and assay conditions
• Peptide fragments may exhibit signalling profiles distinct from full-length pancreatic polypeptide
• Buffer composition, pH, and ionic strength may affect peptide stability
• Appropriate experimental controls are recommended
• Intended strictly for laboratory research use; not for human or veterinary application