Crystagen 20mg

Description

Description & Mechanism

Crystagen is a short synthetic tripeptide (EDP), identified as one of the bioactive short peptides within the thymic preparation Thymalin, used as a molecular probe for studying immune / lymphoid gene regulation in experimental systems. In cellular models it is studied for effects on lymphocyte proliferation and T-cell-associated markers (e.g. CD3+, CD4+ populations and the CD4+/CD8+ ratio).

Consistent with the Khavinson model, EDP is studied as a cell-penetrating peptide that may bind double-stranded DNA and/or histones to influence expression of immune-system genes. It functions in the laboratory as a research probe for short-peptide / chromatin interaction and immune gene-expression studies; observed effects depend on concentration, model system and exposure conditions.

Applications in Research

• In-vitro lymphocyte proliferation and T-cell marker assays (CD3+/CD4+, CD4+/CD8+)
• Cellular models of immune / thymic gene regulation and immunosenescence
• Studies of EDP as a defined active component of the Thymalin peptide complex
• Probe for short-peptide DNA/histone-binding studies

Specifications Summary

Handling, Reconstitution & Stability

• Weigh under dry conditions; peptide is hygroscopic
• Reconstitute in sterile water or appropriate buffered aqueous solution depending on assay requirements
• Avoid vigorous agitation during dissolution
• Filter sterilize if required (e.g. 0.22 µm) prior to use
• Aliquot and store reconstituted solutions at –20 °C or below to minimise degradation
• Avoid repeated freeze–thaw cycles

Precautions & Notes

• Experimental behaviour is dependent on concentration, model system and exposure conditions
• As an immunomodulatory research peptide, appropriate experimental controls are recommended
• Prolonged exposure to light, elevated temperature or aqueous environments may reduce stability
• Intended strictly for laboratory research use; not for human or veterinary application