Description

Description & Mechanism

GHK-Cu is a naturally occurring copper–peptide complex that functions as an endogenous signalling molecule involved in metal ion transport and cellular regulation. It consists of the tripeptide glycyl-L-histidyl-L-lysine complexed with a divalent copper ion, forming a high-affinity chelate that facilitates controlled copper delivery within biological systems. In biochemical and cellular research settings, GHK-Cu modulates cellular signalling processes through both peptide-mediated interactions and copper-dependent biochemical activity.

Copper is an essential trace element required for numerous enzymatic and structural proteins involved in redox balance, extracellular matrix organisation, and cellular metabolism. By acting as a carrier and regulator of bioavailable copper, GHK-Cu plays a role in maintaining metal homeostasis and influencing downstream pathways linked to cellular growth, differentiation, and tissue remodelling.

In preclinical research models, exposure to GHK-Cu has been associated with altered gene expression patterns and modulation of signalling pathways related to extracellular matrix dynamics, oxidative stress response, and cellular turnover. These effects are context-dependent and vary with concentration, exposure duration, and experimental system, making GHK-Cu a widely used molecular tool for investigating copper-mediated signalling and peptide–metal interactions in vitro and in vivo.

Applications in Research

As a molecular probe to study copper transport, binding, and homeostasis in biological systems.
To investigate copper-dependent signalling pathways involved in cellular growth, differentiation, and tissue remodelling.
In cell-based assays examining changes in gene expression, redox-sensitive signalling, and extracellular matrix regulation.
In animal or ex vivo experimental models for mechanistic investigation of peptide–metal interactions, copper bioavailability, and metal-mediated tissue signalling processes.

Specifications Summary

Parameter	Typical Value / Range
Purity (HPLC)	≥ 99
Appearance	Blue to deep blue lyophilised powder
Molecular Weight	403.92 g/mol
Compound Type	Copper-binding tripeptide
Solubility	Water, dilute acids, DMSO
Storage	–20 °C, desiccated, dark
Pack Size	3,000 mg (bulk)

Handling, Reconstitution & Stability

Weigh under inert/dry conditions; avoid moisture uptake.
Avoid metal-chelating agents (e.g. EDTA) or buffers that may disrupt copper coordination.
For stock solutions, dissolve in sterile water or appropriate buffered aqueous solution depending on assay requirements.
Filter sterilize if needed (e.g. 0.22 µm) immediately prior to use.
Aliquot and store stock solutions at –20 °C (or lower) to avoid repeated freeze–thaw.
Monitor for precipitation or pH shifts before use in sensitive assays.

Precautions & Notes

GHK-Cu activity is concentration-dependent; perform appropriate dose–response controls.
Copper coordination may be affected by pH, ionic strength, and chelating agents.
Light exposure and prolonged aqueous storage may reduce stability.
Intended strictly for laboratory research use; not for human or veterinary application.

Volume Pricing
Spend £150+ (20% off)	£23.12
Spend £500+ (30% off)	£20.23

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GHK-CU 50mg

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