Spend £150 for 20% Off  |   Spend £500 for 30% Off

My Account

Checkout

Customer Support

B7-33 6mg
B7-33 6mg
B7-33 6mg
B7-33 6mg
B7-33 6mg
B7-33 6mg
B7-33 6mg

B7-33 6mg

£49.90

  • OP Labs formerly Oxford Peptides
  • Batch tested Purity: ≥ 98.5 % (HPLC, typical)
  • CAS Number: 42464-96-0
  • Molecular Formula: C₁₀H₁₁N₂⁺
Volume Pricing
Spend £150+ (20% off)£23.12
Spend £500+ (30% off)£20.23

Spending over £1000? Email us your order and we will custom price.

Free shipping on orders over £20

  • Royal Mail Tracked24
  • Order before 16.00 for same day dispatch
  • Money Back Guarantee

Guaranteed Safe Checkout

ALL ARTICLES AND PRODUCT INFORMATION PROVIDED ON THIS WEBSITE ARE FOR INFORMATIONAL AND EDUCATIONAL PURPOSES ONLY.

The products offered on this website are furnished for in-vitro studies only. In-vitro studies are performed outside of the body. These products are not medicines or drugs and have not been approved to prevent, treat or cure any medical condition, ailment or disease. Bodily introduction of any kind into humans or animals is strictly forbidden.

Description

Description & Mechanism

B7-33 is a 26-residue single-chain peptide derived from the B-chain of human relaxin-2. In research contexts it is studied as a molecular probe for signalling through the relaxin family peptide receptor 1 (RXFP1), a G protein-coupled receptor, providing a defined single-chain alternative to recombinant two-chain relaxin for receptor-pharmacology studies.

In cell-based assays B7-33 behaves as a functionally selective (“biased”) agonist, preferentially engaging the pERK1/2 signalling arm with comparatively weaker cAMP accumulation relative to native relaxin-2. In cultured fibroblast and tissue models, RXFP1 engagement has been used to interrogate TGF-β/Smad2 signalling and matrix metalloproteinase expression. Observed responses are dependent on experimental conditions, concentration and model system; the peptide is used as a molecular probe rather than for defined physiological outcomes.

Applications in Research

  • In-vitro characterisation of RXFP1 receptor pharmacology and biased/functionally selective GPCR signalling (cAMP vs pERK assays)
  • Cellular models of fibrosis (cardiac, renal, pulmonary, hepatic fibroblast cultures) examining collagen / TGF-β signalling
  • Preclinical rodent models of adverse cardiac remodelling as a relaxin mimetic
  • Structure–activity / minimal-pharmacophore studies of relaxin-derived single-chain peptides

Specifications Summary

Parameter Typical Value / Range
Purity (HPLC) ≥ 99 %
Appearance White to off-white lyophilised powder
Molecular Weight 2986.58 g/mol
Peptide Type Synthetic single-chain relaxin-family peptide (RXFP1 receptor agonist)
Solubility Water, buffered aqueous solutions
Storage –20 °C, desiccated, dark
Pack Size 6 mg (total)

Handling, Reconstitution & Stability

  • Weigh under dry conditions; peptide is hygroscopic
  • Reconstitute in sterile water or appropriate buffered aqueous solution depending on assay requirements
  • Avoid vigorous agitation during dissolution
  • Filter sterilize if required (e.g. 0.22 µm) prior to use
  • Aliquot and store reconstituted solutions at –20 °C or below to minimise degradation
  • Avoid repeated freeze–thaw cycles

Precautions & Notes

  • Experimental behaviour is dependent on concentration, model system and exposure conditions
  • As a receptor agonist, appropriate vehicle and receptor-negative controls are recommended
  • Prolonged exposure to light, elevated temperature or aqueous environments may reduce stability
  • Intended strictly for laboratory research use; not for human or veterinary application

Related products