Ovagen 20mg

Description

Description & Mechanism

Ovagen (EDL) is studied in vitro as a short tissue-specific peptide probe for hepatic and gastrointestinal epithelial signalling. In experimental models it is proposed to enter cells and act at the chromatin/transcriptional level, modulating expression of genes associated with hepatocyte proliferation and epithelial homeostasis.

Within the Khavinson “peptide regulation of gene expression” framework, EDL serves as a reference compound for testing tissue-selective effects on proliferation/apoptosis markers (e.g. Ki-67, p53) in cultures derived from young versus aged tissue. It is a molecular probe; observed effects depend on concentration, model system and exposure conditions.

Applications in Research

• In-vitro study of hepatocyte / GI-epithelial gene-expression regulation in organotypic cultures
• Comparative tissue-specificity screening across the Khavinson bioregulator panel
• Preclinical models of hepatic stress / regeneration (cell-culture and rodent)
• Reference probe for short-peptide chromatin / transcription studies

Specifications Summary

Handling, Reconstitution & Stability

• Weigh under dry conditions; peptide is hygroscopic
• Reconstitute in sterile water or appropriate buffered aqueous solution depending on assay requirements
• Avoid vigorous agitation during dissolution
• Filter sterilize if required (e.g. 0.22 µm) prior to use
• Aliquot and store reconstituted solutions at –20 °C or below to minimise degradation
• Avoid repeated freeze–thaw cycles

Precautions & Notes

• Experimental behaviour is dependent on concentration, model system and exposure conditions
• Appropriate experimental controls are recommended
• Prolonged exposure to light, elevated temperature or aqueous environments may reduce stability
• Intended strictly for laboratory research use; not for human or veterinary application