Cortagen 20mg

Description

Description & Mechanism

Cortagen is a short synthetic tetrapeptide, designed on the basis of amino-acid analysis of the cortical polypeptide preparation Cortexin, used as a molecular probe for studying tissue-specific gene regulation in nervous-tissue model systems. In experimental settings it is applied to neuronal and glial cultures and to peripheral-nerve regeneration models to examine neurotrophic gene expression, cell proliferation and neurite outgrowth.

In line with the Khavinson short-peptide paradigm, Cortagen is studied as a candidate cell-penetrating regulator that may bind DNA/histones and modulate promoter activity. It serves as a research tool for probing transcriptional mechanisms in experimental neuroscience preparations; observed effects depend on concentration, model system and exposure conditions.

Applications in Research

• Preclinical rodent peripheral-nerve regeneration models (e.g. sciatic-nerve transection)
• In-vitro neuronal / glial culture gene-expression and neurite-outgrowth assays
• Cellular models of neuroprotection and oxidative stress
• Probe for short-peptide transcriptional regulation in neural tissue

Specifications Summary

Handling, Reconstitution & Stability

• Weigh under dry conditions; peptide is hygroscopic
• Reconstitute in sterile water or appropriate buffered aqueous solution depending on assay requirements
• Avoid vigorous agitation during dissolution
• Filter sterilize if required (e.g. 0.22 µm) prior to use
• Aliquot and store reconstituted solutions at –20 °C or below to minimise degradation
• Avoid repeated freeze–thaw cycles

Precautions & Notes

• Experimental behaviour is dependent on concentration, model system and exposure conditions
• Appropriate experimental controls are recommended
• Prolonged exposure to light, elevated temperature or aqueous environments may reduce stability
• Intended strictly for laboratory research use; not for human or veterinary application