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Bronchogen 20mg
Bronchogen 20mg
Bronchogen 20mg
Bronchogen 20mg
Bronchogen 20mg
Bronchogen 20mg
Bronchogen 20mg

Bronchogen 20mg

£26.90

  • OP Labs formerly Oxford Peptides
  • Batch tested Purity: ≥ 98.5 % (HPLC, typical)
  • CAS Number: 42464-96-0
  • Molecular Formula: C₁₀H₁₁N₂⁺
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ALL ARTICLES AND PRODUCT INFORMATION PROVIDED ON THIS WEBSITE ARE FOR INFORMATIONAL AND EDUCATIONAL PURPOSES ONLY.

The products offered on this website are furnished for in-vitro studies only. In-vitro studies are performed outside of the body. These products are not medicines or drugs and have not been approved to prevent, treat or cure any medical condition, ailment or disease. Bodily introduction of any kind into humans or animals is strictly forbidden.

Description

Description & Mechanism

Bronchogen is a short synthetic tetrapeptide used as a molecular probe for studying tissue-specific regulation of gene expression in bronchial-epithelium model systems. In cultured human bronchial epithelial cells it has been reported to modulate transcription of mucin and surfactant-associated genes (MUC4, MUC5AC, SFTPA1) and to alter levels of proliferation- and apoptosis-associated proteins.

Within the Khavinson short-peptide model, peptides of this class are studied as candidate cell-penetrating regulators that may interact with DNA and chromatin to influence promoter activity. Bronchogen is therefore used to examine putative peptide–DNA interactions and downstream transcriptional readouts in vitro; observed effects depend on concentration, model system and exposure conditions.

Applications in Research

  • In-vitro modulation of gene/protein expression in human bronchial epithelial cell cultures (MUC4, MUC5AC, SFTPA1, Ki-67, p53)
  • Cellular models of epithelial proliferation, apoptosis and replicative senescence
  • Preclinical rodent models of experimental lung inflammation, fibrosis and toxic lung injury
  • Probe compound for short-peptide / DNA-promoter interaction studies

Specifications Summary

Parameter Typical Value / Range
Purity (HPLC) ≥ 99 %
Appearance White to off-white lyophilised powder
Molecular Weight 446.45 g/mol
Peptide Type Synthetic linear tetrapeptide bioregulator (Khavinson cytogen family)
Solubility Water, buffered aqueous solutions
Storage –20 °C, desiccated, dark
Pack Size 20 mg (total)

Handling, Reconstitution & Stability

  • Weigh under dry conditions; peptide is hygroscopic
  • Reconstitute in sterile water or appropriate buffered aqueous solution depending on assay requirements
  • Avoid vigorous agitation during dissolution
  • Filter sterilize if required (e.g. 0.22 µm) prior to use
  • Aliquot and store reconstituted solutions at –20 °C or below to minimise degradation
  • Avoid repeated freeze–thaw cycles

Precautions & Notes

  • Experimental behaviour is dependent on concentration, model system and exposure conditions
  • Appropriate experimental controls are recommended
  • Prolonged exposure to light, elevated temperature or aqueous environments may reduce stability
  • Intended strictly for laboratory research use; not for human or veterinary application

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