KPV 5mg

Description

Description & Mechanism

KPV is a synthetic tripeptide corresponding to amino acids 11–13 of α-melanocyte-stimulating hormone (α-MSH). It represents the minimal bioactive fragment commonly utilised in research settings to investigate melanocortin-associated signalling independently of the full-length peptide.

In biochemical and cellular research systems, KPV has been studied for its interactions with melanocortin-related pathways and downstream intracellular signalling mechanisms associated with immune modulation and inflammatory responses. Experimental studies typically examine receptor-independent and receptor-associated signalling effects, transcriptional responses, and peptide stability under controlled conditions. Observed molecular responses are dependent on experimental design, concentration, and model system, and are used to explore peptide-mediated signalling rather than defined biological or physiological outcomes.

Applications in Research

• As a molecular probe for studying melanocortin-related signalling pathways
• Investigation of peptide-mediated modulation of inflammatory and immune-associated cellular responses
• In vitro studies examining short peptide signalling and stability
• Use as a reference compound in melanocortin and α-MSH fragment research

Handling, Reconstitution & Stability

• Weigh under dry conditions; peptide is hygroscopic
• Reconstitute in sterile water or appropriate buffered aqueous solution depending on assay requirements
• Avoid vigorous agitation during dissolution
• Filter sterilize if required (e.g. 0.22 µm) immediately prior to use
• Aliquot and store reconstituted solutions at –20 °C (or lower)
• Avoid repeated freeze–thaw cycles

Specifications Summary

Purity: ≥ 99 %
Appearance: White to off-white lyophilised powder
Peptide Type: Synthetic α-MSH–derived tripeptide
Molar Weight: ~342.43 g/mol
Solubility: Water, buffered aqueous solutions
Storage: –20 °C, desiccated, protected from light
Pack Size: 5 mg

Precautions & Notes

• Experimental behaviour of KPV is influenced by concentration, exposure duration, and experimental model
• Short peptide fragments may exhibit signalling profiles distinct from parent hormones
• Buffer composition, pH, and ionic strength may affect peptide stability and assay performance
• Appropriate controls are recommended to distinguish specific from non-specific effects
• Intended strictly for laboratory research use; not for human or veterinary application