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LL37 5mg
LL37 5mg
LL37 5mg
LL37 5mg
LL37 5mg
LL37 5mg
LL37 5mg

LL37 5mg

£29.95

  • OP Labs formerly Oxford Peptides
  • Batch tested Purity: ≥ 98.5 % (HPLC, typical)
  • CAS Number: 42464-96-0
  • Molecular Formula: C₁₀H₁₁N₂⁺
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Spend £500+ (30% off)£20.23

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ALL ARTICLES AND PRODUCT INFORMATION PROVIDED ON THIS WEBSITE ARE FOR INFORMATIONAL AND EDUCATIONAL PURPOSES ONLY.

The products offered on this website are furnished for in-vitro studies only. In-vitro studies are performed outside of the body. These products are not medicines or drugs and have not been approved to prevent, treat or cure any medical condition, ailment or disease. Bodily introduction of any kind into humans or animals is strictly forbidden.

Description

Description & Mechanism

LL-37 is a 37-amino acid peptide derived from the C-terminal domain of human cathelicidin (hCAP-18). It is the only cathelicidin-derived antimicrobial peptide identified in humans and is widely used as a research tool for investigating innate immune defence mechanisms in experimental systems.

In biochemical and cellular research models, LL-37 has been reported to interact with bacterial membranes and modulate host immune signalling pathways. Observed activities include membrane disruption in microbial models, modulation of inflammatory mediator release, and influence on cell migration and proliferation in in vitro assays. Experimental outcomes are highly dependent on concentration, model system, and assay conditions.

Applications in Research

  • As a molecular tool to study host-defence peptide activity and innate immune signalling
  • Investigation of antimicrobial peptide–membrane interactions in microbial model systems
  • In vitro studies examining immunomodulatory effects on cytokine and chemokine release
  • Preclinical or ex vivo experimental models for mechanistic investigation of cathelicidin biology

Specifications Summary

Parameter Typical Value / Range
Purity (HPLC) ≥ 98
Appearance White to off-white lyophilised powder
Molecular Weight 4493.33 g/mol
Peptide Type Synthetic cathelicidin-derived antimicrobial peptide
Solubility Water, buffered aqueous solutions
Storage −20 °C, desiccated, dark
Pack Size 5 mg

Handling, Reconstitution & Stability

  • Weigh under dry conditions; peptide is hygroscopic
  • Reconstitute in sterile water or appropriate buffered aqueous solution depending on assay requirements
  • Avoid vigorous agitation during dissolution
  • Filter sterilize if required (e.g. 0.22 μm) prior to use
  • Aliquot and store reconstituted solutions at −20 °C or below to minimise degradation
  • Avoid repeated freeze–thaw cycles

Precautions & Notes

  • Experimental behaviour of LL-37 is dependent on concentration, model system, and exposure conditions
  • Due to reported interaction with multiple immune signalling pathways, appropriate experimental controls are recommended
  • Prolonged exposure to light, elevated temperature, or aqueous environments may reduce stability
  • Intended strictly for laboratory research use; not for human or veterinary application

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