MGF 2mg

Description

Description & Mechanism

MGF (Mechano Growth Factor) is a synthetic peptide derived from the E-domain of the IGF-1 Ec splice variant. It is used in research settings to investigate mechanotransduction-associated signalling, IGF-related peptide processing, and splice-variant–specific peptide behaviour in cellular and molecular models.

In experimental systems, MGF is studied as a distinct molecular entity from full-length IGF-1, with research focusing on peptide stability, receptor interactions, and downstream signalling responses under controlled in vitro conditions. Observed effects are dependent on experimental design, peptide concentration, and model system, and are evaluated for mechanistic insight rather than defined physiological outcomes.

Applications in Research:

• Investigation of IGF-1 splice variant biology and peptide processing
• Studies of mechanotransduction-related signalling pathways
• In vitro research examining peptide–receptor and peptide–matrix interactions
• Use as a reference peptide in growth factor and muscle biology research

Handling, Reconstitution & Stability

• Handle under dry conditions; peptide is hygroscopic
• Reconstitute in sterile water or appropriate buffered aqueous solution
• Avoid vigorous agitation during dissolution
• Aliquot after reconstitution to minimise degradation
• Store reconstituted solutions at –20 °C or below
• Avoid repeated freeze–thaw cycles

Specifications Summary

Purity: ≥ 99 % (analytical HPLC, typical)
Appearance: White to off-white lyophilised powder
Peptide Type: Synthetic IGF-1 splice variant–derived peptide (MGF / IGF-1Ec)
Molecular Weight: 2867.1 g/mol
Solubility: Water, buffered aqueous solutions
Storage: –20 °C, desiccated, protected from light
Pack Size: Commonly supplied as 1 mg or 5 mg

Precautions & Notes

• Experimental behaviour of MGF is influenced by concentration, exposure duration, and experimental model
• As a short peptide derived from an IGF-1 splice variant, MGF may exhibit signalling characteristics distinct
from full-length IGF-1
• Buffer composition, pH, and enzymatic activity may affect peptide stability
• Peptide fragments may demonstrate rapid degradation in some in vitro systems; appropriate controls are recommended
• Intended strictly for laboratory research use; not for human or veterinary application