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PTD-DBM 5mg
PTD-DBM 5mg
PTD-DBM 5mg
PTD-DBM 5mg
PTD-DBM 5mg
PTD-DBM 5mg
PTD-DBM 5mg

PTD-DBM 5mg

£80.90

  • OP Labs formerly Oxford Peptides
  • Batch tested Purity: ≥ 98.5 % (HPLC, typical)
  • CAS Number: 42464-96-0
  • Molecular Formula: C₁₀H₁₁N₂⁺
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Spend £500+ (30% off)£20.23

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ALL ARTICLES AND PRODUCT INFORMATION PROVIDED ON THIS WEBSITE ARE FOR INFORMATIONAL AND EDUCATIONAL PURPOSES ONLY.

The products offered on this website are furnished for in-vitro studies only. In-vitro studies are performed outside of the body. These products are not medicines or drugs and have not been approved to prevent, treat or cure any medical condition, ailment or disease. Bodily introduction of any kind into humans or animals is strictly forbidden.

Description

Description & Mechanism

PTD-DBM is a rationally designed research peptide used to disrupt the protein–protein interaction between CXXC5 (a negative-feedback regulator of Wnt/β-catenin signalling) and Dishevelled (Dvl). The Dishevelled-binding motif competes with CXXC5 for the same docking surface on Dvl, while the octa-arginine protein transduction domain enables intracellular delivery in cell and tissue models.

By displacing CXXC5 from Dvl, the peptide de-represses Wnt/β-catenin signalling in experimental systems, used as a molecular tool to study β-catenin stabilisation and target-gene transcription. In the originating work it was applied to rodent skin to study hair-follicle biology and wound-induced hair-follicle neogenesis. All applications are mechanistic/preclinical; observed effects depend on concentration and model system.

Applications in Research

  • In-vitro disruption of the CXXC5–Dvl protein–protein interaction to study Wnt/β-catenin signalling
  • Cellular reporter assays (e.g. TOPflash / β-catenin transcriptional activity)
  • Preclinical rodent hair-follicle research (hair regrowth and wound-induced hair neogenesis)
  • Cell-penetrating peptide delivery and cutaneous wound-healing models

Specifications Summary

Parameter Typical Value / Range
Purity (HPLC) ≥ 99 %
Appearance White to off-white lyophilised powder
Molecular Weight ~3082.62 g/mol (supplier analytical data)
Peptide Type Synthetic cell-penetrating peptide (CPP) / protein–protein-interaction inhibitor peptide
Solubility Water, buffered aqueous solutions
Storage –20 °C, desiccated, dark
Pack Size 5 mg (total)

Handling, Reconstitution & Stability

  • Weigh under dry conditions; peptide is hygroscopic
  • Reconstitute in sterile water or appropriate buffered aqueous solution depending on assay requirements
  • Avoid vigorous agitation during dissolution
  • Filter sterilize if required (e.g. 0.22 µm) prior to use
  • Aliquot and store reconstituted solutions at –20 °C or below to minimise degradation
  • Avoid repeated freeze–thaw cycles

Precautions & Notes

  • Highly cationic, arginine-rich peptide containing two cysteines — handle under reducing/inert conditions to limit disulfide oxidation
  • Experimental behaviour is dependent on concentration, model system and exposure conditions
  • Prolonged exposure to light, elevated temperature or aqueous environments may reduce stability
  • Intended strictly for laboratory research use; not for human or veterinary application

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