Vesugen 20mg

Description

Description & Mechanism

Vesugen (KED) is studied in vitro as a vascular / endothelium-directed short-peptide probe. In organotypic and dissociated cell cultures it has been reported to stimulate the proliferation marker Ki-67 (which declines with age) and to reduce apoptosis (decreased p53), used experimentally to study endothelial cell renewal and vascular-tissue gene-expression programmes.

Within the Khavinson model it is a tool for probing chromatin-level transcriptional regulation in vascular and neuroimmunoendocrine cell systems, including comparative young-versus-old culture studies. Observed effects depend on concentration, model system and exposure conditions.

Applications in Research

• In-vitro endothelial / vascular cell proliferation and apoptosis-marker studies
• Neuroimmunoendocrine organotypic-culture gene-expression research
• Preclinical models of vascular aging (cell culture and rodent)
• Reference probe for short-peptide transcriptional regulation

Specifications Summary

Handling, Reconstitution & Stability

• Weigh under dry conditions; peptide is hygroscopic
• Reconstitute in sterile water or appropriate buffered aqueous solution depending on assay requirements
• Avoid vigorous agitation during dissolution
• Filter sterilize if required (e.g. 0.22 µm) prior to use
• Aliquot and store reconstituted solutions at –20 °C or below to minimise degradation
• Avoid repeated freeze–thaw cycles

Precautions & Notes

• Experimental behaviour is dependent on concentration, model system and exposure conditions
• Appropriate experimental controls are recommended
• Prolonged exposure to light, elevated temperature or aqueous environments may reduce stability
• Intended strictly for laboratory research use; not for human or veterinary application