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ALL ARTICLES AND PRODUCT INFORMATION PROVIDED ON THIS WEBSITE ARE FOR INFORMATIONAL AND EDUCATIONAL PURPOSES ONLY.
The products offered on this website are furnished for in-vitro studies only. In-vitro studies are performed outside of the body. These products are not medicines or drugs and have not been approved to prevent, treat or cure any medical condition, ailment or disease. Bodily introduction of any kind into humans or animals is strictly forbidden.
FOXO4-DRI is a synthetic, modified peptide derived from regions of the Forkhead box O4 (FOXO4) transcription factor. It was engineered using a D-retro-inverso design to improve stability and resistance to proteolytic degradation in experimental systems.
In biochemical and cellular research models, FOXO4-DRI has been used to study protein–protein interactions between FOXO4 and p53. The peptide acts as a competitive inhibitor of this interaction, enabling investigation of transcriptional regulation, cellular senescence pathways, and stress-response signalling. Observed effects are dependent on experimental design, concentration, and model system, and are used for mechanistic exploration rather than defined biological outcomes.
• Investigation of FOXO4–p53 protein–protein interactions
• Study of cellular senescence and transcription factor regulation
• In vitro models examining stress-response signalling pathways
• Use as a research tool in aging and cell-cycle biology studies
• Handle under dry, clean laboratory conditions
• Reconstitute in sterile water or appropriate buffered solution
• Avoid vigorous agitation during dissolution
• Aliquot reconstituted solutions to avoid repeated freeze–thaw cycles
• Store reconstituted material at –20 °C or below for long-term stability
Purity: ≥ 98 % (HPLC)
Appearance: White to off-white lyophilised powder
Peptide Type: Synthetic modified research peptide
Molecular Weight: 5358.05 g/mol
Solubility: Water, buffered aqueous solutions
Storage: –20 °C, desiccated, protected from light
• Intended strictly for laboratory research use
• Not for human or veterinary application
• Experimental outcomes may vary depending on model system and assay design
• Appropriate controls are recommended to interpret pathway-specific effects
